Which following development in the 1620s had fatally adverse, long-ter

Which following development in the 1620s had fatally adverse, long-term implications for Indians in Virginia?

A) the conversion of Virginia from a royally chartered colony to a company colony in 1624
B) the sending of thousands of Christian missionaries to convert the Indians from England to Virginia in the 1620s
C) the shift from trade with Indians to tobacco-based agriculture by English settlers in the region
D) the massive attack by the Algonquians in 1622 on the English settlers of Virginia

ANSWER
Answer: C